(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431)

J Med Chem. 1995 Sep 1;38(18):3445-7. doi: 10.1021/jm00018a002.
No abstract available

MeSH terms

  • Acetylation
  • Animals
  • Behavior, Animal / drug effects
  • Drug Administration Schedule
  • Humans
  • Prodrugs / chemistry
  • Prodrugs / pharmacology*
  • Protein Precursors / metabolism
  • Pyridines / chemistry
  • Pyridines / pharmacology*
  • Quinolones*
  • Rats
  • Receptors, Dopamine D1 / agonists*
  • Receptors, Dopamine D1 / metabolism
  • Receptors, Dopamine D2 / metabolism
  • Structure-Activity Relationship
  • Tetrahydronaphthalenes / chemistry
  • Tetrahydronaphthalenes / pharmacology*
  • Thiophenes*

Substances

  • Prodrugs
  • Protein Precursors
  • Pyridines
  • Quinolones
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Tetrahydronaphthalenes
  • Thiophenes
  • adrogolide hydrochloride
  • A 86929